conception

What-are-the-main-symptoms-of-hormonal-imbalance?

What are the main symptoms of hormonal imbalance?

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When hormones are at balanced levels, a person feels vibrant and energetic, sleeps soundly and deeply, maintains normal weight and good concentration. However, when hormones are in imbalance, i.e. at low or elevated levels than normal,&nbsp; then we are talking about hormonal imbalance. And since these chemical messengers are interrelated, disruption in the rhythm of one hormone leads to dysregulation of other important hormones.

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The right balance of hormones is essential for effective reproductive cycles such as the process of ovulation in women and the overall system of conception. For men, hormones are crucial in terms of male sexual characteristics, reproductive abilities and libido.

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The human body uses more than fifty hormones to guide various systems and bodily functions such as growth, metabolism and temperature regulation, sleep and wakefulness cycles, and more. A hormonal imbalance is an incorrect amount of one or more hormones in the blood. The timing of hormone(s) release, interactions with other hormones, and the ability to respond through cellular receptors are also important for hormonal balance. It has been shown that an imbalance of hormones associated with reproductive health in one or both partners can make it difficult to conceive and pregnancy. Hormonal imbalances are also the leading cause of infertility in women, but they are often treatable with lifestyle changes and medications, and some phytotherapeutics can act positively.

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Hormonal imbalance can also cause infertility in men, but it is a less common factor of infertility in men than in women.

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The most common symptoms of hormone imbalance in women are:

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<ul><li style="font-weight: 400;" aria-level="1">Lack of menstrual cycle</li><li style="font-weight: 400;" aria-level="1">Irregular menstrual cycle</li><li style="font-weight: 400;" aria-level="1">Abundant or painful menstruation.</li><li style="font-weight: 400;" aria-level="1">Increased hair on the face, neck, chest and back</li><li style="font-weight: 400;" aria-level="1">Unexplained weight gain</li><li style="font-weight: 400;" aria-level="1">Constipation and diarrhea</li><li style="font-weight: 400;" aria-level="1">Low libido</li></ul>In men, the following symptoms may occur:

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<ul><li style="font-weight: 400;" aria-level="1">Erectile dysfunction</li><li style="font-weight: 400;" aria-level="1">Low sperm count</li><li style="font-weight: 400;" aria-level="1">Reduced growth of body hair</li><li style="font-weight: 400;" aria-level="1">Breast tenderness and breast tissue overdevelopment</li><li style="font-weight: 400;" aria-level="1">Thinning hair or hair loss male type</li></ul> In case of symptoms of hormonal imbalance, it is important to seek medical attention to do the necessary tests. Then determine the mode of treatment and therapy, which may include hormone replacement therapy, medications, herbal and other means.

Herbs-and-natural-remedies-for-hormonal-imbalance

Herbs and natural remedies for hormonal imbalance

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Herbs are a group of plants whose leaves, flowers, roots and seeds are used for a variety of purposes, including therapeutic. It is important to clarify from the beginning that the use of herbs to balance hormone levels is not recommended for every person. Herbal medicine has proven its usefulness and effectiveness over time, yet some herbal remedies may be safe for some, but dangerous for others.

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Women who are pregnant, breastfeeding, using hormone therapy, living with endocrine or mental disorders, or having cancer are at risk of dangerous side effects associated with taking certain herbs. Therefore, they should always consult a doctor before taking herbs and natural remedies for hormonal imbalance.

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For the rest, there is a palette of herbs and natural remedies that work for different types of hormonal changes. Let's see in particular what the opportunities and benefits are.

Seeds-of-Nigella-sativa-(Black-cumin)

Seeds of Nigella sativa (Black cumin)

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Nigella sativa is also known as kalonji, chelebattle and others. Its flowers produce small black seeds rich in antioxidants. These seeds have healing properties because they contain thymoquinone – a type of phytonutrient or plant compound.

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Researchers investigated the protective and therapeutic effects of nigella seeds in women with polycystic ovary syndrome (PCOS). PCOS is a disorder associated with abnormal hormone levels, among other symptoms, in women of reproductive age. <a href="https://www.jrmds.in/articles/the-effects-of-nigella-sativa-hydroalcoholic-extract-and-honey-on-lipid-profile-and-indices-of-insulin-resistance-in-polycystic-ov.pdf" target="_blank" data-ref="" rel="noopener">[ref.</a>&nbsp;1]&nbsp;

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In animal studies, nigella seed extracts have helped regulate levels of insulin, testosterone, luteinizing hormone, and thyroid hormones, among others. &nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/27247926/" target="_blank" data-ref="Effect of Nigella sativa on reproductive system in experimental menopause rat model - PubMed" rel="noopener">[ref. 2]</a>&nbsp;

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In addition, Nigella sativa extract exhibits estrogenic activity, which means it acts similarly to the hormone estrogen in your body. This would obviously not be appropriate if you have increased estrogen in the body.&nbsp;

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With regard to these seeds, note that most studies were conducted on animals and concentrated extracts or isolated thymoquinone were used. There are still a limited number of studies on this action of nigella seeds in humans.

Ashwagandha-(Withania-somnifera)

Ashwagandha (Withania somnifera) 

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Ashwagandha, also known as winter cherry, Indian ginseng or Withania somnifera, is an evergreen shrub of the Solanaceae family. Ashwagandha is highly revered in herbal medicine, being used in many supplements, teas and powders.

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This adaptogen is thought to help the body overcome stress by moderating the hypothalamic-pituitary-adrenal (HPA) axis of the brain. This axis produces and releases numerous hormones including cortisol that initiate your body's response to stress. Cortisol helps you get through stressful and stressful moments. However, according to studies in humans and rats, chronic hormone imbalance can cause endocrine disorders such as Addison's disease and Cushing's syndrome. These are some of the possibilities of applying ashwagandha to regulate the hormone cortisol. &nbsp;<a href="https://journals.lww.com/md-journal/Fulltext/2019/09130/An_investigation_into_the_stress_relieving_and.67.aspx" target="_blank" data-ref="An investigation into the stress-relieving and... : Medicine" rel="noopener">[ref. 3]</a>&nbsp;

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Ashwagandha can also affect other hormones. For example, researchers are investigating how it alters insulin levels, reproductive hormones, and more, gathering enough data for more definitive claims. Another important thing about this Ayurvedic star is that it may not be safe for pregnant and breastfeeding women, as well as for people with autoimmune diseases or thyroid disorders.

Vitex-agnus-castus-(Vitex-agnus-castus)

Vitex agnus-castus (Vitex agnus castus) 

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Vitex agnus castus (also known as Chaste Wood and Abraham Tree) is a multifaceted herb for hormonal problems in women. It has remarkable hormonal balancing activity and has been used by herbalists for centuries for menstrual problems, cycle regulation, increased fertility, and to help women during menopause.&nbsp;

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Vitext works by supporting the hypothalamus gland (a gland in the brain that controls the hormonal system). It is known to balance a woman's estrogen/progesterone ratio (the main reproductive hormones) by increasing progesterone and lowering estrogen accordingly. So, vitex is especially useful in conditions with low progesterone, including a short menstrual cycle, irregular cycle, PMS, and acne. &nbsp;<a href="https://linkinghub.elsevier.com/retrieve/pii/S0965229919306053" target="_blank" data-ref="Redirecting" rel="noopener">[ref. 4]</a>&nbsp;

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Vitex agnus may also lower prolactin levels and increase LH (luteinizing hormone). High prolactin has been linked to infertility and cycle arrest in women. LH is the hormone that helps control the menstrual cycle and causes ovulation (the release of an egg from the ovaries). With various hormonal disorders of this type of vitex, agnus castus has applications. &nbsp;<a href="https://link.springer.com/article/10.1007/s00737-017-0791-0?error=cookies_not_supported&amp;code=42a1055e-91b3-4075-a0a0-b962462e69c8" target="_blank" data-ref="Vitex agnus castus for premenstrual syndrome and premenstrual dysphoric disorder: a systematic review - Archives of Women's Mental Health" rel="noopener">[ref. 5]</a>&nbsp;

Peony-(Paeonia-lactiflora)

Peony (Paeonia lactiflora)  

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Peony (Paeonia lactiflora) is a type of herb whose roots are commonly used in traditional Chinese medicine for many purposes. Peony can block chemicals that can cause pain and swelling. It can also prevent blood clotting, kill cancer cells, and act as an antioxidant. &nbsp;<a href="https://linkinghub.elsevier.com/retrieve/pii/S0378874119324900" target="_blank" data-ref="Redirecting" rel="noopener">[ref. 6]</a>&nbsp; It can be combined with other plants to maintain hormones (often in combination with vitex).

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Peoniflorin is one of the active ingredients in the plant. It has anti-inflammatory, antispasmodic and sedative action. In vitro experiments have also shown that it can affect ovarian follicles through its action on the enzyme called aromatase. This enzyme is widely found throughout the body, especially in the ovaries, liver and adipose tissues.

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Peony works to normalize aromatase activity, as well as reduce androgen production. Excess androgens can manifest as extra facial and body hair, cystic acne, female pattern baldness (mostly PCOS symptoms and also after menopause). &nbsp;<a href="https://www.hindawi.com/journals/bmri/2020/4690504/" target="_blank" data-ref="Effects of Paeonia lactiflora Extract on Estrogen Receptor &beta;, TPH2, and SERT in Rats with PMS Anxiety" rel="noopener">[ref. 7]</a>&nbsp;

Angelica-sinensis

Angelica sinensis  

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Angelica sinensis is known as female ginseng because of its numerous therapeutic effects on the female reproductive system.&nbsp;

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Considered blood-building and tonic, Dong Kwai is used by herbalists to enrich a woman's blood supply, strengthen the uterus, promote blood circulation, and increase blood flow to the reproductive system — all key to a regular, healthy menstrual cycle.&nbsp;

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Dong Kwai contains compounds called coumarins, which have been shown to relax the muscles of the uterus and reduce inflammation, making this plant suitable for menstrual cramps. It is also useful for symptoms of PMS and menopause, such as hot flashes. <a href="https://cuaj.ca/index.php/journal/article/view/775" target="_blank" data-ref="		Dong Quai (angelica sinensis) in the treatment of hot flashes for men on androgen deprivation therapy: results of a randomized double-blind placebo controlled trial							| Canadian Urological Association Journal			" rel="noopener">[ref.</a> &nbsp;8]&nbsp;

Hormone levels in the human body are constantly changing. There are hundreds of reasons why they vary daily, and to some extent these ups and downs are necessary. Nevertheless, long-term hormonal imbalances can negatively affect your health. The use of herbal and natural remedies is one of many natural ways to deal with such changes in hormone levels. Each of the five herbs discussed in this article has the potential to help you balance your hormone levels if they are right for you and there are no contraindications. Ask a doctor before taking these herbs.

Symptoms of Hormonal Imbalance - What you need to know (part 2)

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Бетина Цветкова

What-is-ovarian-hyperstimulation-syndrome?

1. What is ovarian hyperstimulation syndrome?

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In both mentioned types of ARTs, ovulation is stimulated to obtain a larger number of oocytes (eggs), which will provide a higher number of embryos later after fertilization. Both types of assisted reproductive technologies require the intake of hormones or medications by the female in order to stimulate ovulation. Gonadotropins- follicle-stimulating hormone (FSH) and lutenizing hormone (LH), or medications such as clomiphene citrate and <a href="https://pubmed.ncbi.nlm.nih.gov/25905247/" target="_blank" data-ref="Evaluation of Infertility, Ovulation Induction and Assisted Reproduction - PubMed" rel="noopener">letrozole are most commonly used [ref. 1]</a>. Although useful for stimulating egg production, medications taken during ART therapy could also be associated with ovarian hyperstimulation syndrome. This condition is temporary, usually lasting for 2 <a href="https://www.mayoclinic.org/diseases-conditions/ovarian-hyperstimulation-syndrome-ohss/diagnosis-treatment/drc-20354703" target="_blank" data-ref="Ovarian hyperstimulation syndrome - Diagnosis and treatment - Mayo Clinic" rel="noopener">weeks [ref. 2]</a> . Here are some of the symptoms of this syndrome caused by increased levels of estrogen and progesterone &nbsp;<a href="https://click.endnote.com/viewer?doi=10.1016%2Fj.fertnstert.2016.08.048&amp;token=WzM0OTU4NTgsIjEwLjEwMTYvai5mZXJ0bnN0ZXJ0LjIwMTYuMDguMDQ4Il0.wPEM7BzsMvwvFKGeQHaAqGRgwUE" target="_blank" data-ref="Prevention and treatment of moderate and severe ovarian hyperstimulation syndrome: a guideline | EndNote Click" rel="noopener">[ref. 3]</a>&nbsp;:

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<ul><li>headaches</li><li>abdominal pain/swelling</li><li>nausea/vomiting</li><li>diarrhea</li><li>hot flushes</li><li>sudden mood swings</li></ul>In rarer cases, ovarian hyperstimulation syndrome can proceed with more severe symptoms:

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<ul><li>severe abdominal pain</li><li>decreased frequency of urination</li><li>breathlessness (tachypnea)</li><li>sudden weight gain</li><li>increased heart rate (tachycardia)</li></ul>

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Treatment-of-ovarian-hyperstimulation-syndrome

2. Treatment of ovarian hyperstimulation syndrome

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With proper treatment, the symptoms of ovarian hyperstimulation syndrome can be managed without any effects on pregnancy. Standard painkillers are used to relieve malaise that is caused by the mild form of ovarian hyperstimulation [ref. 3]. For the abdominal discomfort, painkillers such as paracetamol (acetaminophen/tylenol) can be taken [ref. 2]. It is important to avoid taking ibuprofen or naproxen sodium, as they may interfere with the implantation of the embryo in the uterus.

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In severe cases of ovarian hyperstimulation syndrome, stronger painkillers and antiemetics are used to prevent vomiting [ref. 3]. Prescriptions include cabergoline or&nbsp; Gonadotropin-releasing hormone antagonist, which reduces the function of the ovaries, therefore reduces the symptoms [ref. 2]. The drug letrozole also aids relieving the symptoms of the disease. Daily consultation with a medical practitioner and conducting tests to monitor fluid retention, weight gain, haematocrit levels, electrolytes&nbsp; and serum creatinine [ref. 3] are mandatory.

Herbal-treatment

3. Herbal treatment

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Some types of herbs have a proven positive effect on stimulating a more balanced mood, therefore they would be useful for the mood swings associated with the mild form of ovarian hyperstimulation. It is important to note that prescribing herbs is not a licensed profession, but herbal suppliers and some doctors are certified &nbsp;for carrying out <a href="https://americanpregnancy.org/getting-pregnant/herbs-for-fertility/" target="_blank" data-ref="Herbs for Fertility" rel="noopener">this activity [ref. 4]</a> . Before taking any herbs, it is important to always consult with the supplier, since some types of herbs have a negative effect on pregnancy.

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The results of a scientific study show that symptoms of ovarian hyperstimulation syndrome can be treated more effectively by combined intake of standard Western treatment with Chinese herbal drugs, including ginseng, remania, offia and others &nbsp;<a href="https://www.dynamicchiropractic.com/mpacms/at/article.php?id=31821" target="_blank" data-ref="Ovarian Hyperstimulation Syndrome and Chinese Medicine" rel="noopener">[ref. 5]</a>&nbsp;.

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Examples of herbs helping with abrupt mood swings are:

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St. John's wort, which is usually used to relieve menopausal syndromes, acts as an antidepressant and relieves psychological symptoms such as sudden mood <a href="https://pubmed.ncbi.nlm.nih.gov/10623319/" target="_blank" data-ref="St. John's Wort extract: efficacy for menopausal symptoms of psychological origin - PubMed" rel="noopener">swings [ref. 6]</a> . Also, results of another scientific study involving 100 middle-aged women who suffered from hot flushes demonstrated significant symptom relief after 8 weeks of daily intake <a href="https://pubmed.ncbi.nlm.nih.gov/20216274/" target="_blank" data-ref="Effect of St John's wort on severity, frequency, and duration of hot flashes in premenopausal, perimenopausal and postmenopausal women: a randomized, double-blind, placebo-controlled study - PubMed" rel="noopener">of St. John's</a> &nbsp;wort [ref. 7]&nbsp;.

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Passion flower is a herb,&nbsp; found as 500 different species. The herb aids promoting of a more balanced mood and its effect can be strengthened by a combined intake with St. John's wort <a href="https://bmcpsychiatry.biomedcentral.com/articles/10.1186/1471-244X-11-123" target="_blank" data-ref="Early effect of NEURAPAS&reg;balance on current source density (CSD) of human EEG - BMC Psychiatry" rel="noopener">and valerian [ref. 8]</a>&nbsp;.

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Ginseng is an antidepressant known worldwide that increases the quality of life and stimulates good <a href="http://www.koreascience.or.kr/article/JAKO200718317170332.page" target="_blank" data-ref="												Effects of 8 weeks administration of Korean Panax ginseng extract on the mood and cognitive performance of healthy individuals				-Journal of Ginseng Research						 | Korea Science" rel="noopener">mood [ref. 8]</a>. A scientific study involving&nbsp; 8-week daily intake of a 250 milligrams of ginseng demonstrated that this herb leads to an improved mood and increases quality of life.

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Rhodiola Rosea is another herb known for its natural antidepressant properties. Daily intake of the herb for a period of 14 days by patients suffering from a mild form of anxiety lead to a significant <a href="https://pubmed.ncbi.nlm.nih.gov/26502953/" target="_blank" data-ref="The Effects of Rhodiola rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms - PubMed" rel="noopener">improvement in mood [ref. 9]</a>&nbsp;. Reduced levels of stress, anxiety, anger, confusion and depression were observed after the two-week intake of the herb.

Two of the most commonly used ARTs are the in vitro fertilization and intracytoplasmic sperm injection. A common step in the process of both techniques is the stimulation of ovulation for egg extraction. This is achieved by intaking hormones or medications which can lead to ovarian hyperstimulation syndrome. The mild form of this condition can be treated with standard painkillers, while with more severe symptoms, stricter medical intervention and frequent medical diagnostic tests are essential. Chinese herbal remedies help alleviate the symptoms of the syndrome. St. John's wort, Passion fruit, Ginseng and Rhodiola Rosea have a scientifically proven effect on improving the abrupt mood swings. St. John's wort has another beneficial effect- the relief of hot flushes which are the other common symptom of ovarian hyperstimulation syndrome.&nbsp;

What is ovarian hyperstimulation syndrome and how to combat its symptoms?

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Fight against ovarian hyperstimulation syndrome

Dayana Ivanova

What-is-polycystic-ovary-syndrome-(PCOS)

What is polycystic ovary syndrome (PCOS)

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Polycystic ovary syndrome ( PCOS) is a hormonal imbalance in which the ovaries (the organs that produce and release eggs) are affected, creating an excess of male hormones. If you have PCOS, your ovaries produce abnormally high levels of hormones called androgens. This leads to an imbalance of reproductive hormones and disrupts the entire hormonal background in the body, leading to other health problems and disorders.&nbsp;

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As a result, women with polycystic ovary syndrome often have an irregular menstrual cycle, miss monthly menstruation or have unpredictable ovulation. Small cysts can develop on the ovaries (fluid-filled bags) due to lack of ovulation (anovulation). However, although the name of the condition is 'achievable', you do not necessarily have cysts on your ovaries to develop PCOS. The condition can develop without them.

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Some of the most important facts regarding polycystic ovary syndrome (PCOS) that you need to know are:

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<ul><li style="font-weight: 400;" aria-level="1">Many women suffer from polycystic ovary syndrome without being aware of it. A study shows that up to 70% of women suffering from this disease are not diagnosed. [&nbsp;<a href="https://academic.oup.com/jcem/article/102/2/604/2972079" target="_blank" data-ref="Delayed Diagnosis and a Lack of Information Associated With Dissatisfaction in Women With Polycystic Ovary Syndrome" rel="noopener">[ref. 1]</a>&nbsp;]&nbsp;</li><li style="font-weight: 400;" aria-level="1">A woman can develop PCOS at any time after puberty. Most women are diagnosed in their 20s or 30s when trying to get pregnant. Research shows that polycystic ovary syndrome is transmitted by inheritance. [&nbsp;<a href="https://link.springer.com/article/10.1385/ENDO:30:1:19?error=cookies_not_supported&amp;code=b5683b1b-1b01-46cc-ad97-682a72958184" target="_blank" data-ref="The role of genes and environment in the etiology of PCOS - Endocrine" rel="noopener">[ref. 2]</a>&nbsp;</li><li style="font-weight: 400;" aria-level="1">You may have a higher chance of developing PCOS if you are overweight or obese, or if other people in your family have PCOS. [&nbsp;<a href="https://academic.oup.com/jes/article/3/8/1545/5518341" target="_blank" data-ref="Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls" rel="noopener">[ref. 3]</a>&nbsp;]&nbsp;</li><li style="font-weight: 400;" aria-level="1">Rotterdam criteria have been established, according to which "Polycystic ovary syndrome (PCOS) is determined by the presence of two out of three of the following criteria: oligoanovulation, hyperandrogenism and polycystic ovaries (&ge; 12 follicles with a diameter of 2-9 mm and/or ovarian volume 10 ml in at least one ovary)." [&nbsp;<a href="https://onlinelibrary.wiley.com/doi/10.1002/ajum.12096" target="_blank" data-ref="Just a moment..." rel="noopener">[ref. 4]</a>&nbsp;] together with ultrasound examination and other diagnostic methods, they can facilitate better and early diagnosis of PCOS, reducing health risks.</li><li style="font-weight: 400;" aria-level="1">About 70% of women with polycystic ovary syndrome have insulin resistance, which means that their cells cannot use insulin properly. [&nbsp;<a href="https://linkinghub.elsevier.com/retrieve/pii/S0015028211028123" target="_blank" data-ref="Redirecting" rel="noopener">[ref. 5]</a>&nbsp;] Insulin is a hormone produced by the pancreas. It helps the body use sugar from food to generate energy. When cells do not consume insulin properly<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277302/" target="_blank" rel="noopener">, the body's need for it increases</a>. The pancreas produces more insulin to compensate for this. Excess insulin causes the ovaries to produce more androgens (male hormones).</li></ul>

The-most-popular-symptoms-of-polycystic-ovary-syndrome-(PCOS)

The most popular symptoms of polycystic ovary syndrome (PCOS)

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Some women face symptoms around their first cycle. Others found they had ovarian cancer after gaining a lot of extra weight or having difficulty conceiving. Imbalance in the menstrual cycle can also be a signal that a woman suffers from PCOS.

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The most common symptoms of this disease are:

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<ul><li style="font-weight: 400;" aria-level="1">Irregular menstruation. The absence of ovulation interferes with the monthly discharge of the surface layer of the uterine mucosa (endometrium). Some women with polycystic have less than eight menstruations per year, and there are cases in which the menstrual cycle is completely absent. [ <a href="https://www.womenshealth.gov/a-z-topics/polycystic-ovary-syndrome" target="_blank" data-ref="Polycystic ovary syndrome | Office on Women's Health" rel="noopener">[ref. 6]</a>&nbsp;]&nbsp;</li><li style="font-weight: 400;" aria-level="1">Severe bleeding. The endometrium becomes more massive, therefore the menstruations are heavier than usual.&nbsp;</li><li style="font-weight: 400;" aria-level="1">More than 70% of women with this disease have facial hair appearing at unusual areas of the body - back, abdomen, breasts. Excessive body hair in these areas is called hirsutism. [&nbsp;<a href="http://www.eurekaselect.com/article/77195" target="_blank" data-ref="Hirsutism in Polycystic Ovary Syndrome: Pathophysiology and Management" rel="noopener">[ref. 7]</a>&nbsp;]</li><li style="font-weight: 400;" aria-level="1">Acne. Male hormones (androgens) can make the skin oilier than usual and cause skin imperfections in areas such as the face, chest and upper back.</li><li style="font-weight: 400;" aria-level="1">Weight gain. Up to 80 percent of women with PCOS are overweight or obese, as cited by the American College of Obstetricians and Gynecologists. [&nbsp;<a href="https://www.acog.org/womens-health/faqs/polycystic-ovary-syndrome-pcos?utm_source=redirect&amp;utm_medium=web&amp;utm_campaign=otn" target="_blank" data-ref="Polycystic Ovary Syndrome (PCOS)" rel="noopener">[ref. 8]</a>&nbsp;]&nbsp;</li><li style="font-weight: 400;" aria-level="1">Male pattern&nbsp;baldness. Hair on the scalp becomes thinner and can fall out more.</li><li style="font-weight: 400;" aria-level="1">Darkening of the skin. Dark spots on the skin can form in folds on the body, such as those of the neck, in the groin and under the chest.</li><li style="font-weight: 400;" aria-level="1">Headache. Hormonal changes can cause headaches in some women.</li><li style="font-weight: 400;" aria-level="1">Low-grade inflammation: Women with PCOS tend to have chronic low-legrade inflammation. The healthcare professional you are targeting can perform blood tests that measure levels of C-reactive protein (CRP) and white blood cells to check for such inflammation in the body.</li></ul>

Herbal-treatments-for-polycystic-ovary-syndrome-(PCOS)

Herbal treatments for polycystic ovary syndrome (PCOS)

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According to a study conducted by Iranian and German scientists, published on June 3, 2019 [&nbsp;<a href="https://www.mdpi.com/2218-273X/9/6/215" target="_blank" data-ref="The Effectiveness of Herbal Mixture Supplements with and without Clomiphene Citrate in Comparison to Clomiphene Citrate on Serum Antioxidants and Glycemic Biomarkers in Women with Polycystic Ovary Syndrome Willing to Be Pregnant: A Randomized Clinical Trial" rel="noopener">[ref. 9]</a>&nbsp;], supplements from herbal mixtures, in combination with clomiphene citrate (CC), have a beneficial effect on serum antioxidant levels, as well as on glycaemic biomarkers in polycystic ovary syndrome, causing infertility, regulation of menstruation and successful conception.&nbsp;

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The herbs studied are:&nbsp;

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<ul><li style="font-weight: 400;" aria-level="1">Mint (Mentha spicata) [&nbsp;<a href="https://www.herbal-organic.com/bg/herb/14450" target="_blank" data-ref="Mentha" rel="noopener">[ref. 10]</a>&nbsp;]&nbsp;</li><li style="font-weight: 400;" aria-level="1">Ginger (Zingiber officinale) [&nbsp;<a href="https://www.herbal-organic.com/bg/pubmed/Zingiber_officinale_ginger_Monograph_12946242" target="_blank" data-ref="Zingiber officinale (ginger). Monograph. | Билкови и природни лекарства" rel="noopener">[ref. 11]</a>&nbsp;]&nbsp;</li><li style="font-weight: 400;" aria-level="1">Ceylon cinnamon (Cinnamomum zeylanicum) [&nbsp;<a href="https://www.herbal-organic.com/bg/herb/15249" target="_blank" data-ref="Cinnamomum zeylanicum" rel="noopener">[ref. 12]</a>&nbsp;]&nbsp;</li><li style="font-weight: 400;" aria-level="1">Sweet orange (Citrus sinensis<a href="https://www.sciencedirect.com/science/article/abs/pii/S0308814612011533?via%3Dihub" target="_blank" data-ref="Role of Essential Oil of Mentha Spicata (Spearmint) in Addressing Reverse Hormonal and Folliculogenesis Disturbances in a Polycystic Ovarian Syndrome in a Rat Model - PubMed" rel="noopener">) [</a>&nbsp;[ref. 13]&nbsp;</li></ul>Next, we will take a brief overview of the main health-friendly properties of each of these herbs.

Beneficial-properties-of-herbs-in-PCOS-and-other-health-conditions

Beneficial properties of herbs in PCOS and other health conditions

Mint-(Mentha-spicata)

Mint (Mentha spicata) 

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Mentha spicata (mint) of the Lamiaceae family, a widespread plant in the temperate belt has anti-inflammatory, antidiabetic and anticancer effect [&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/29399556/" target="_blank" data-ref="Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review" rel="noopener">[ref. 14]</a>&nbsp;. Some studies confirm that mint contains various volatile compounds such as p-cimen, isopiperitone, mentone and &beta;-linalool and various phenolic phytocompositions, which are not only considered an antioxidant source, but also reduce glucose levels and oxidative stress.

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Ginger-(Zingiber-officinale)

Ginger (Zingiber officinale)

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The main components of Zingiber officinale Roscoe - a representative of the Zingiberaceae family, are zingiberene, campen and p-cinaol, which show antioxidant, anticancer, anti-clotting and anti-inflammatory properties. In addition, ginger significantly reduces serum fasting blood sugar levels and insulin levels, contributes to blood pressure control and supports intestinal health. In vitro and in vivo studies confirm that ginger increases levels of SOD (superoxide dismutase), CAT (catalase) and GPX (glutathione peroxidase), as well as increases the antioxidant capacity in the blood. [&nbsp;<a href="https://www.hindawi.com/journals/ecam/2012/516870/" target="_blank" data-ref="Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review" rel="noopener">[ref. 15]</a>&nbsp;]

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Ceylon-cinnamon-(Cinnamomum-zeylanicum)

Ceylon cinnamon (Cinnamomum zeylanicum) 

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Cinnamomum zeylanicum nees (Cinnamon) from the Lauraceae family is known for its antioxidant and anti-inflammatory properties [&nbsp;<a href="https://linkinghub.elsevier.com/retrieve/pii/S0278691507000889" target="_blank" data-ref="Redirecting" rel="noopener">[ref. 16]</a>&nbsp;]. Cinnamon extract can be used as an antioxidant due to its phenolic content, especially cynamaldehyde, which improves the level of superoxide dismutase, catalase and glutathione peroxidase, and reduces the concentration of MDA (malonal dialdehyde), as well as increases the possibility of becoming pregnant. In addition, it significantly reduces insulin and blood sugar, which is obviously key in women with polycystic ovary syndrome.

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Sweet-Orange-(Citrus-sinensis)

Sweet Orange (Citrus sinensis)

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Citrus Sinensis (L.) Osbeck of the Rutaceae family contains mainly hesperidine, polymetoxylated flavonoids and terpenoids (&nbsp; citric and linalool). These phenolic bioactive compounds show significant cytoprotective effects (protecting cells) against oxidative stress created by free radicals. In addition, hesperidine in C. sinensis increases levels of antioxidants, including superoxide dismutase and catalase, and reduces the level of malonal dialdehyde.&nbsp;

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According to the results of a team of scientists who conducted a randomized blind study on the effectiveness of herbal extracts in PCOS, the herbal mixture of four components - mint, ginger, Ceylon cinnamon and sweet orange, demonstrated powerful antioxidant activity. It is due to the total content of phenols and flavonoids. As the study shows, supplements from herbal mixtures, together with clomiphene citrate, can have a beneficial effect on serum antioxidant levels, as well as on glycaemic biomarkers of infertility in PCOS, regulating menstruation and increasing the chance of becoming pregnant. Ginger with a wide range of antioxidants and polyphenol compounds such as β-carotene, ascorbic acid, terpenoids, alkaloids, and polyphenols such as flavonoids, flavon glycosides, is considered the richest source of phytochemical antioxidants. Phenolic phytochemicals of mint significantly improve antioxidant protection. The bark of C. sinensis is also very rich in phenolic compounds, including flavonoids and phenolic acids, which can be consumed as natural antioxidants. These natural remedies can help with a variety of health problems, including overweight, impaired immunity, high blood pressure and obesity, as well as polycystic ovary syndrome (PCOS).

Effectiveness of herbal supplements in polycystic ovary syndrome (PCOS)

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Effectiveness of herbal supplements in polycystic ovary syndrome 

Asparagus-Health-Benefits

Asparagus Health Benefits

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Many-nutrients-with-minimal-calories

Many nutrients with minimal calories

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Asparagus Officinalis is low in calories but has an impressive nutrient profile. [&nbsp;<a href="https://www.herbal-organic.com/bg/herb/15248" target="_blank" data-ref="Asparagus officinalis" rel="noopener">[ref. 1]</a>&nbsp;] In fact, only half a cup (90 grams) of cooked asparagus contains only 20 calories and the following nutrients:

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<ul><li style="font-weight: 400;" aria-level="1">Protein: 2.2 grams</li><li style="font-weight: 400;" aria-level="1">Fat: 0.2 grams</li><li style="font-weight: 400;" aria-level="1">Fiber: 1.8 grams</li><li style="font-weight: 400;" aria-level="1">Vitamin C: 12% (% RDA)</li><li style="font-weight: 400;" aria-level="1">Vitamin A: 18% (% RDA)</li><li style="font-weight: 400;" aria-level="1">Vitamin K: 57% (% RDA)</li><li style="font-weight: 400;" aria-level="1">Folate: 34% (% RDA)</li><li style="font-weight: 400;" aria-level="1">Potassium: 6% (% RDA)</li><li style="font-weight: 400;" aria-level="1">Phosphorus: 5% (% RDA)</li><li style="font-weight: 400;" aria-level="1">Vitamin E: 7% (% RDA)</li></ul>Asparagus also contains small amounts of other trace elements, including iron, zinc and riboflavin. These elements are important for normal cell function and energy production. Asparagus is also an excellent source of vitamin K, a major nutrient involved in blood clotting and bone health. [&nbsp;<a href="https://openheart.bmj.com/content/2/1/e000300" target="_blank" data-ref="The health benefits of vitamin K" rel="noopener">[ref. 2]</a>&nbsp;]

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In addition, asparagus is high in folic acid, a nutrient that is vital for normal pregnancy and many important processes in the body, including cell growth and DNA formation. [&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218540/" target="_blank" data-ref="403 Error - NCBITwitterFacebookLinkedInGitHubSM-TwitterSM-FacebookSM-Youtube" rel="noopener">[ref. 3]</a>&nbsp;]

A-good-source-of-antioxidants

A good source of antioxidants

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Antioxidants are compounds that help protect your cells from the harmful effects of free radicals and oxidative stress. Oxidative stress contributes to aging, chronic inflammation and many diseases, including cancer. Asparagus, like other green vegetables, is high in antioxidants. These include vitamin E, vitamin C and glutathione, as well as various flavonoids and polyphenols. Asparagus&nbsp;<a href="https://onlinelibrary.wiley.com/doi/10.1002/jsfa.2825" target="_blank" data-ref="Just a moment..." rel="noopener">is also particularly rich</a> in flavonoids ivercetin, isoramnetin and kempferol. [&nbsp;<a href="https://www.food.actapol.net/volume15/issue3/abstract-4.html" target="_blank" data-ref="Kulczyński B., Kobus-Cisowska J., Kmiecik D., Gramza-Michałowska A., Golczak D., Korczak J., 2016. Antiradical capacity and polyphenol composition of asparagus spears varieties cultivated under different sunlight conditions. Acta Sci.Pol. Technol. Aliment. 15 (3), 267-279" rel="noopener">[ref. 5]</a>&nbsp;

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If that doesn't seem like enough: purple asparagus contains powerful pigments called anthocyanins, which give the vegetable its vibrant color and have antioxidant effects in the body. [&nbsp;<a href="https://linkinghub.elsevier.com/retrieve/pii/S0031942208001131" target="_blank" data-ref="Redirecting" rel="noopener">[ref. 6]</a>&nbsp;]&nbsp;

May-improve-digestive-health

May improve digestive health

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Dietary fiber is essential for good digestion. Only half a cup of asparagus provides 1.8 grams of fiber, which is 7% of daily needs.

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Studies have shown that a diet high in fiber-rich fruits and vegetables can help reduce the risk of high blood pressure, heart disease and diabetes. [&nbsp;<a href="https://www.bmj.com/content/347/bmj.f6879" target="_blank" data-ref="Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis" rel="noopener">[ref. 7]</a>&nbsp;

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Helps-maintain-a-healthy-pregnancy

Helps maintain a healthy pregnancy 

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Asparagus is an excellent source of folic acid, also known as vitamin B9, which is necessary even before conception itself, as well as during pregnancy. Only half a cup of asparagus provides adults with 34% of their daily folic acid needs, and pregnant women 22% of their daily needs. Getting enough folic acid from sources such as asparagus, green leafy vegetables and fruits can protect against neural tube defects, including spina bifida. [&nbsp;<a href="https://www.mdpi.com/2072-6643/5/11/4760" target="_blank" data-ref="Folate Deficiency and Folic Acid Supplementation: The Prevention of Neural-Tube Defects and Congenital Heart Defects" rel="noopener">[ref. 8]</a>&nbsp;]

Asparagus is a nutritious and delicious food that can be easily prepared to your liking. They are low in calories and are a great source of important nutrients, including fiber, folic acid and vitamins A, C and K. In addition, eating asparagus has a number of potential health benefits, including weight loss support, improved digestion, a healthy pregnancy rate and lower blood pressure.