Muscular dystrophy (MD) is a group of muscle diseases that results in increasing weakening and breakdown of skeletal muscles over time. The disorders differ in which muscles are primarily affected, the degree of weakness, how fast they worsen, and when symptoms begin. Many people will eventually become unable to walk. Some types are also associated with problems in other organs.The muscular dystrophy group contains thirty different genetic disorders that are usually classified into nine main categories ...

muscular dystrophies

_-1_0

Symptoms-associated-with-low-creatinine-levels

Symptoms associated with low creatinine levels

Symptoms-associated-with-low-creatinine-levels_0_0

Some common symptoms of low creatinine levels include:

Symptoms-associated-with-low-creatinine-levels_0_1

<ul><li style="font-weight: 400;" aria-level="1">Fatigue</li><li style="font-weight: 400;" aria-level="1">Muscle weakness</li><li style="font-weight: 400;" aria-level="1">Unintentional weight loss</li><li style="font-weight: 400;" aria-level="1">Difficulty concentrating</li></ul>

Causes-of-Low-Creatinine-Levels-and-Relevant-Healthcare-Professionals

Causes of Low Creatinine Levels and Relevant Healthcare Professionals

Causes-of-Low-Creatinine-Levels-and-Relevant-Healthcare-Professionals_1_0

Causes-of-Low-Creatinine-Levels-and-Relevant-Healthcare-Professionals_1_1

<ul><li>Hepatitis, cirrhosis, or liver failure can lead to low creatinine levels</li><li>Consult a hepatologist or gastroenterologist for diagnosis and treatment</li></ul>Malnutrition:

Causes-of-Low-Creatinine-Levels-and-Relevant-Healthcare-Professionals_1_2

<ul><li>Poor diet and lack of essential nutrients can result in low creatinine levels</li><li>Consult a nutritionist or dietitian for dietary recommendations</li></ul>Muscular Dystrophy:

Causes-of-Low-Creatinine-Levels-and-Relevant-Healthcare-Professionals_1_3

<ul><li>A group of genetic diseases causing progressive muscle weakness and loss of muscle mass</li><li>Consult a neurologist for diagnosis and treatment</li></ul>Aging:

Causes-of-Low-Creatinine-Levels-and-Relevant-Healthcare-Professionals_1_4

<ul><li>Natural loss of muscle mass and strength due to aging can lead to low creatinine levels</li><li>Consult a geriatrician or primary care physician for age-related health concerns</li></ul>Pregnancy:

Causes-of-Low-Creatinine-Levels-and-Relevant-Healthcare-Professionals_1_5

<ul><li>Increased blood volume during pregnancy can dilute creatinine levels</li><li>Consult an obstetrician or gynecologist for prenatal care</li></ul>

Causes-of-Low-Creatinine-Levels-and-Relevant-Healthcare-Professionals_1_6

Side-effects-of-drugs-that-can-cause-low-creatinine-levels

Side effects of drugs that can cause low creatinine levels

Side-effects-of-drugs-that-can-cause-low-creatinine-levels_2_0

<ul><li style="font-weight: 400;" aria-level="1">Statins: cholesterol-lowering drugs</li><li style="font-weight: 400;" aria-level="1">Angiotensin-converting enzyme (ACE) inhibitors: blood pressure medications</li><li style="font-weight: 400;" aria-level="1">Nonsteroidal anti-inflammatory drugs (NSAIDs): pain relievers such as ibuprofen</li></ul>

Herbal-and-natural-remedies-for-low-creatinine-levels:

Herbal and natural remedies for low creatinine levels:

Herbal-and-natural-remedies-for-low-creatinine-levels:_3_0

Echinacea (Echinacea purpurea):

Herbal-and-natural-remedies-for-low-creatinine-levels:_3_1

<ul><li>Supports immune system function</li><li>May help improve liver function</li></ul>Milk Thistle (Silybum marianum):

Herbal-and-natural-remedies-for-low-creatinine-levels:_3_2

<ul><li>Contains silymarin, a powerful antioxidant</li><li>Promotes liver health and regeneration</li></ul>Astragalus (Astragalus membranaceus):

Herbal-and-natural-remedies-for-low-creatinine-levels:_3_3

<ul><li>May increase energy levels and improve muscle strength</li><li>Supports immune system function</li></ul>Ashwagandha (Withania somnifera):

Herbal-and-natural-remedies-for-low-creatinine-levels:_3_4

<ul><li>Adaptogenic herb that helps the body adapt to stress</li><li>May promote muscle growth and strength</li></ul>

Herbal-and-natural-remedies-for-low-creatinine-levels:_3_5

Lifestyle-Changes-to-Improve-Creatinine-Levels

Lifestyle Changes to Improve Creatinine Levels

Lifestyle-Changes-to-Improve-Creatinine-Levels_4_0

<ul><li style="font-weight: 400;" aria-level="1">Consume a balanced diet with adequate protein intake</li><li style="font-weight: 400;" aria-level="1">Engage in regular exercise to maintain muscle mass</li><li style="font-weight: 400;" aria-level="1">Stay hydrated to ensure proper kidney function</li><li style="font-weight: 400;" aria-level="1">Avoid excessive alcohol consumption</li><li style="font-weight: 400;" aria-level="1">Get adequate sleep and manage stress levels</li></ul>

Questions-and-Answers

Questions and Answers 

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:

Below are ten frequently asked questions that are not covered in the article:

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_0

Q: Can dehydration cause low creatinine levels?

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_1

A: Dehydration can cause an increase in creatinine levels, not a decrease.

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_2

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_3

Q: Is creatinine level related to kidney function?

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_4

A: Yes, creatinine levels are used to evaluate kidney function, but low creatinine levels typically do not indicate kidney problems.

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_5

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_6

Q: Can high protein intake cause low creatinine levels?

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_7

A: High protein intake may result in increased creatinine levels. Low creatinine levels are more likely due to low protein intake or other factors mentioned in the article.

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_8

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_9

Q: Are low creatinine levels in urine the same as low creatinine levels in blood?

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_10

A: No, low creatinine levels in urine might indicate a kidney problem, while low creatinine levels in blood are more likely related to muscle mass or liver function.

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_11

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_12

Q: How often should I check my creatinine levels?

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_13

A: Consult your healthcare provider for personalized recommendations. Regular check-ups are advisable, especially if you have any risk factors or are experiencing symptoms.

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_14

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_15

Q: Can stress cause low creatinine levels?

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_16

A: While stress itself is unlikely to directly cause low creatinine levels, it may contribute to factors that lead to low creatinine levels, such as muscle loss or malnutrition.

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_17

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_18

Q: Are low creatinine levels dangerous?

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_19

A: Low creatinine levels are not inherently dangerous, but they may be indicative of underlying health issues that need to be addressed.

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_20

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_21

Q: Can low creatinine levels cause fatigue?

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_22

A: Fatigue can be a symptom of low creatinine levels, as it may be related to the underlying causes, such as liver disease or malnutrition.

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_23

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_24

Q: Can I improve my creatinine levels with supplements?

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_25

A: Consult your healthcare provider before starting any new supplements. While some supplements may help address underlying causes of low creatinine levels, it is essential to identify the specific cause to ensure appropriate treatment.

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_26

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_27

Q: Are there any foods I should avoid if I have low creatinine levels?

Below-are-ten-frequently-asked-questions-that-are-not-covered-in-the-article:_5_28

A: There are no specific foods that you need to avoid. However, it is essential to consume a balanced diet with adequate protein and nutrients to support overall health and potentially improve creatinine levels.

Low creatinine levels can be caused by various factors, including liver disease, malnutrition, muscular dystrophy, aging, and pregnancy. Certain medications can also contribute to this condition. Herbal and natural treatments, along with lifestyle changes, can help improve creatinine levels and overall health. Consult the appropriate medical professional for diagnosis and treatment.

 Low Creatinine Levels: Causes and Concerns

https://sanatio.s3.eu-west-1.amazonaws.com/982fbd6b-e4aa-4466-99d0-cecc5cd0e5dd_middle.jpg

Екипът на Санацио

Photo by National Cancer Institute on Unsplash

<ul><li style="font-weight: 400;" aria-level="1">Fatigue</li><li style="font-weight: 400;" aria-level="1">Muscle weakness</li><li style="font-weight: 400;" aria-level="1">Difficulty concentrating</li><li style="font-weight: 400;" aria-level="1">Frequent infections</li></ul>

Possible-causes-and-related-diseases

Possible causes and related diseases

Malnutrition

1. Malnutrition

Malnutrition_1_0

<ul><li style="font-weight: 400;" aria-level="2">Lack of proper nutrition can lead to low creatinine levels</li><li style="font-weight: 400;" aria-level="2">Consult a dietitian or nutritionist for guidance on a balanced diet</li></ul>

Liver-disease

2. Liver disease

Liver-disease_1_0

<ul><li style="font-weight: 400;" aria-level="2">Impaired liver function can cause decreased creatinine production</li><li style="font-weight: 400;" aria-level="2">Consult a hepatologist or gastroenterologist for diagnosis and treatment</li></ul>

Diseases-of-muscle-loss

3. Diseases of muscle loss

Diseases-of-muscle-loss_1_0

<ul><li style="font-weight: 400;" aria-level="2">Muscular dystrophy, multiple sclerosis, or other conditions can lead to decreased muscle mass and reduced creatinine production</li><li style="font-weight: 400;" aria-level="2">Consult a neurologist or physiatrist for appropriate care</li></ul>

Pregnancy

4. Pregnancy

Pregnancy_1_0

<ul><li style="font-weight: 400;" aria-level="2">Creatinine levels may decrease due to increased blood volume and kidney filtration during pregnancy</li><li style="font-weight: 400;" aria-level="2">Consult an obstetrician or primary care physician for routine prenatal care</li></ul>

Pregnancy_1_1

Side-effects-of-medical-drugs-that-can-cause-low-creatinine-levels

Side effects of medical drugs that can cause low creatinine levels

Side-effects-of-medical-drugs-that-can-cause-low-creatinine-levels_2_0

<ul><li style="font-weight: 400;" aria-level="1">Corticosteroids</li><li style="font-weight: 400;" aria-level="1">Chemotherapy drugs</li><li style="font-weight: 400;" aria-level="1">Non-steroidal anti-inflammatory drugs (NSAIDs)</li></ul>

Herbal-and-Natural-Treatments-for-Low-Creatinine-Levels

Herbal and Natural Treatments for Low Creatinine Levels

Astragalus-(Astragalus-membranaceus)

1. Astragalus (Astragalus membranaceus)

Astragalus-(Astragalus-membranaceus)_3_0

<ul><li style="font-weight: 400;" aria-level="2">May improve kidney function and overall immunity</li><li style="font-weight: 400;" aria-level="2">Supports liver health and may help combat fatigue</li></ul>

Rhodiola-(Rhodiola-rosea)

2. Rhodiola (Rhodiola rosea)

Rhodiola-(Rhodiola-rosea)_3_0

<ul><li style="font-weight: 400;" aria-level="2">Can help reduce stress and improve energy levels</li><li style="font-weight: 400;" aria-level="2">May support healthy liver function and muscle health</li></ul>

Ashwagandha-(Withania-somnifera)

3. Ashwagandha (Withania somnifera)

Ashwagandha-(Withania-somnifera)_3_0

<ul><li style="font-weight: 400;" aria-level="2">May help combat stress and anxiety</li><li style="font-weight: 400;" aria-level="2">Supports muscle strength and overall vitality</li></ul>

Ashwagandha-(Withania-somnifera)_3_1

Lifestyle-Changes-to-Prevent-Low-Creatinine-Levels

Lifestyle Changes to Prevent Low Creatinine Levels

Lifestyle-Changes-to-Prevent-Low-Creatinine-Levels_4_0

<ul><li style="font-weight: 400;" aria-level="1">Maintain a balanced and nutritious diet</li><li style="font-weight: 400;" aria-level="1">Engage in regular physical activity to support muscle health</li><li style="font-weight: 400;" aria-level="1">Manage stress through mindfulness, meditation, or other relaxation techniques</li><li style="font-weight: 400;" aria-level="1">Get adequate sleep to promote overall health and well-being</li></ul>

Questions and Answers

Q: Can low creatinine levels be a sign of kidney disease?

A: Low creatinine levels are typically not associated with kidney disease, as kidney disease usually results in elevated creatinine levels.

Q: How can I increase my creatinine levels naturally?

A: Consuming a balanced diet, engaging in regular physical activity, and managing stress can help improve overall health and, in turn, creatinine levels.

Q: Are there any specific foods that can help increase creatinine levels?

A: Foods high in protein, such as lean meats, fish, eggs, and dairy products, can help support creatinine production.

Q: Can dehydration affect creatinine levels?

A: Yes, dehydration can cause fluctuations in creatinine levels. Maintaining proper hydration is essential for overall health and accurate creatinine readings.

Q: Can certain medications increase creatinine levels?

A: Yes, some medications, like ACE inhibitors and ARBs, can temporarily increase creatinine levels.

Q: What is the normal range for creatinine levels in a blood test?

A: The normal range for creatinine levels varies by age, sex, and muscle mass. For adult males, it is typically 0.6 to 1.2 mg/dL, and for adult females, it is usually 0.5 to 1.1 mg/dL. Always consult your healthcare provider to understand the specific reference range applicable to you.

Q: Can low creatinine levels be temporary or fluctuate over time?

A: Yes, creatinine levels can fluctuate due to factors such as hydration status, physical activity, and medications. It is essential to monitor creatinine levels over time and consult a healthcare professional if you have concerns.

Q: Can aging affect creatinine levels?

A: Yes, aging can lead to a decrease in muscle mass, which may result in lower creatinine levels. It is essential to maintain a healthy lifestyle and monitor creatinine levels regularly as you age.

Q: How often should I have my creatinine levels checked?

A: The frequency of creatinine level checks depends on your individual health status and risk factors. Consult your healthcare provider for personalized recommendations.

Q: Can a high-protein diet contribute to elevated creatinine levels?

A: While a high-protein diet can lead to a temporary increase in creatinine levels, it is generally not a cause for concern in healthy individuals. However, it is essential to maintain a balanced diet and consult your healthcare provider if you have concerns about your creatinine levels or overall health.

Low creatinine levels can be caused by various factors, such as malnutrition, liver disease, muscle wasting diseases, and pregnancy. Recognizing the symptoms and understanding the potential causes will help you address the issue effectively. Consult a medical professional for proper diagnosis and treatment, and consider natural treatments and lifestyle changes to improve your overall health.

Low Creatinine Levels: Causes and Concerns

https://sanatio.s3.eu-west-1.amazonaws.com/72ef6470-54a1-464b-9879-f8c3e658a70d_middle.jpg

Leber's-congenital-amaurosis

Leber's congenital amaurosis

Leber's-congenital-amaurosis_0_0

U.S. scientists at the University of Pennsylvania were able to achieve a lasting improvement in vision with a single injection of RNA therapy, targeting Leber's congenital amaurosis disease.&nbsp; They reported their results in the journal Nature Medecine&nbsp;<a href="https://www.nature.com/articles/s41591-021-01297-7?error=cookies_not_supported&amp;code=7d18976f-5013-4c77-929e-03dffbb964db" target="_blank" data-ref="Durable vision improvement after a single treatment with antisense oligonucleotide sepofarsen: a case report - Nature Medicine" rel="noopener">[ref. 1]</a> .&nbsp;

Leber's-congenital-amaurosis_0_1

Leber's congenital amaurosis disease primarily affects the retina - the part of the eye that captures light and colors, and converts them into a nerve signal that is sent to the brain. People suffering from this disease usually have severely impaired vision from infancy, or even blindness. It is rarely progressive, but sometimes a worsening of symptoms is observed over time. Some of them include:

Leber's-congenital-amaurosis_0_2

<ul><li style="font-weight: 400;" aria-level="1">curtain of the eyes (cataracts)</li><li style="font-weight: 400;" aria-level="1">uncontrolled movement of the eye</li><li style="font-weight: 400;" aria-level="1">intolerance to bright light</li><li style="font-weight: 400;" aria-level="1">squint</li><li style="font-weight: 400;" aria-level="1">extreme farsightedness&nbsp;, etc.</li></ul>

What-causes-the-disease

What causes the disease 

What-causes-the-disease_1_0

Leber congenital amaurosis is a genetic disease.&nbsp;Mutations in a gene called CEP290 are among the most common causes of developing the disease - between 15 and 22% &nbsp;of cases are due to defects in it <a href="https://medlineplus.gov/genetics/gene/cep290/#:~:text=At%20least%2035%20mutations%20in,associated%20with%20Leber%20congenital%20amaurosis." target="_blank" data-ref="CEP290 gene: MedlinePlus Genetics" rel="noopener">[ref. 2]</a> .

What-causes-the-disease_1_1

One of the most common mutations, 2991+1655A&gt;G, was also the subject of the therapy in the clinical trial conducted at the Scheie Eye Institute in Pennsylvania.

Nature-of-antisense-RNA-therapy

Nature of antisense RNA therapy

Nature-of-antisense-RNA-therapy_2_0

Antisense-RNA oligonucleotides are molecules of RNA that target the messanger RNA (mRNA) of a gene, i.e. the intermediary molecule between the genetic information encoded in the gene and the final functional unit of the cell which is the protein. Binding of the antisense-RNA to the targeted mRNA can lead to a number of consequences, such as its change.&nbsp;

Nature-of-antisense-RNA-therapy_2_1

This is also the purpose of therapy against Leber congenital amaurosis. The main idea of the researche is to inject a specially created antisense-RNA molecule to recognize the early defective mRNA, which would encode the defective CEP290 gene, and change it to eliminate the aforementioned 2991+1655A&gt;G mutation.&nbsp;

Nature-of-antisense-RNA-therapy_2_2

The team recruited 11 patients for the clinical trial suffering from the disease with a detected 2991+1655A&gt;G mutation. The original protocol included an antisense-RNA injection called sepofarsen every 3 months. However, the last patient, patient 11, refused to continue treatment&nbsp; after the first dose, as he felt a significant improvement in symptoms and wanted to reduce the risk of side effects after the administration of subsequent doses of the preparation.

A-single-injection

A single injection 

A-single-injection_3_0

The case of patient 11 is the subject of the article published in Nature Medecine. It is of interest because the patient received only one dose of the therapy, but the results of the follow-up showed that his vision improvement was comparable to that of the other treatment participants who received all the necessary doses.&nbsp;

A-single-injection_3_1

The patient was followed within 15 months after the first and only dose of sesopharsen was administered. The researchers reported significant improvements in the participant's vision and in the structure of his retina, with the peak of efficacy being the third month after therapy. There was a slight decrease in effectiveness by month 15, but nevertheless the symptoms were still significantly improved.

A-single-injection_3_2

A possible explanation, according to the team of researchers, is the slow degradation of the antisenes-RNA entering the nucleus of the cell, as well as the relatively long life of the properly synthesized functional CEP290 protein.

The study is important from medical point of view as it provides valuable guidance in antisense-RNA therapies. This type of treatment is very promising for other diseases as well. Currently, there are exist approved similar therapies for certain neurological conditions as Duchenne muscular dystrophy and Spinal muscular atrophy. Moreover, treatment for Parkinson's, Alzheimer's and Huntington's diseases is under development.

muscular dystrophies

Low Creatinine Levels: Causes and Concerns

Long-term treatment of a genetic form of blindness

What you need to know about collagen and how not to lose it

Spinal muscular atrophy (SMA) - causes, symptoms and treatment