spinal cord

_-1_0

Causes,-Symptoms,-and-Risk-Factors-of-Multiple-Sclerosis

Causes, Symptoms, and Risk Factors of Multiple Sclerosis

Causes,-Symptoms,-and-Risk-Factors-of-Multiple-Sclerosis_0_0

Multiple sclerosis is an autoimmune disorder that occurs when the immune system mistakenly attacks the protective covering of nerve fibers, called myelin. As the myelin gets damaged, the transmission of signals between the brain and body slows down, leading to a range of symptoms. Some common symptoms of MS include fatigue, muscle weakness, vision problems, balance issues, and memory difficulties.

Causes,-Symptoms,-and-Risk-Factors-of-Multiple-Sclerosis_0_1

The exact cause of MS remains unknown, but researchers believe a combination of genetic and environmental factors contribute to the disease. Risk factors include age (most commonly diagnosed between 20 and 50 years old), gender (women are more likely to develop MS), family history, and certain infections.

The-Role-of-Bee-Venom-in-Multiple-Sclerosis-Clinical-Trials

The Role of Bee Venom in Multiple Sclerosis Clinical Trials

The-Role-of-Bee-Venom-in-Multiple-Sclerosis-Clinical-Trials_1_0

Scientific research has been delving into the potential benefits of bee venom in treating MS. One such study conducted by researchers at the University of California, Riverside, demonstrated the potential of melittin, a component of bee venom, to suppress the immune system's overreaction, thereby reducing inflammation and protecting nerve cells.

The-Role-of-Bee-Venom-in-Multiple-Sclerosis-Clinical-Trials_1_1

Another study published in the journal "Nature" found that a specific protein in bee venom, called apamin, could help promote the repair of myelin in laboratory mice with MS-like symptoms. This groundbreaking discovery suggests that apamin could potentially be a future treatment for MS patients.

The-Role-of-Bee-Venom-in-Multiple-Sclerosis-Clinical-Trials_1_2

Despite these promising results, it's essential to note that these studies are still in the early stages, and more extensive clinical trials are necessary to confirm bee venom's efficacy and safety in treating MS.

The-Role-of-Bee-Venom-in-Multiple-Sclerosis-Clinical-Trials_1_3

Recipe-Ideas

Recipe Ideas

Recipe-Ideas_2_0

Although bee venom is not a typical ingredient in recipes, honey, a product made by bees, has a myriad of health benefits and can be incorporated into various dishes. Some easy-to-make options include drizzling honey over yogurt, oatmeal, or toast with almond butter. You can also try using honey in salad dressings, marinades, and desserts.

A-Brief-Note-on-Allergies-and-Medical-Advice

A Brief Note on Allergies and Medical Advice

A-Brief-Note-on-Allergies-and-Medical-Advice_3_0

Before trying any new treatment, it is crucial to consult a healthcare professional, especially if you have a history of allergies or bee sting reactions.

Questions-and-Answers

Questions and Answers

Questions-and-Answers_4_0

Q: Are bee venom and honey the same thing?

Questions-and-Answers_4_1

A: No, bee venom is a toxin produced by bees for self-defense, while honey is a sweet food produced from the nectar of flowers.

Questions-and-Answers_4_2

Questions-and-Answers_4_3

Q: How is bee venom collected without harming the bees?

Questions-and-Answers_4_4

A: Bee venom can be collected using a non-lethal method, such as a venom collector, which uses a gentle electric current to stimulate bees to release venom without harming them.

Questions-and-Answers_4_5

Questions-and-Answers_4_6

Q: Are there any side effects to bee venom therapy?

Questions-and-Answers_4_7

A: Some individuals may experience side effects such as swelling, redness, and pain at the site of the treatment. In some cases, serious allergic reactions can occur, which is why it is crucial to consult a healthcare professional before trying any new treatment, especially if you have a history of allergies or bee sting reactions.

Questions-and-Answers_4_8

Questions-and-Answers_4_9

Q: Can bee venom therapy be used alongside other treatments for MS?

Questions-and-Answers_4_10

A: It is essential to discuss any potential treatments, including bee venom therapy, with your healthcare provider to ensure the safe and effective management of your MS symptoms.

Questions-and-Answers_4_11

Questions-and-Answers_4_12

Q: How long will it take for bee venom to be approved as a treatment for MS?

Questions-and-Answers_4_13

A: The approval process for any new treatment depends on the success of clinical trials and the regulatory steps involved. As bee venom research is still in its early stages, it may take several years before it becomes an approved treatment option for MS patients.

The potential use of bee venom in treating multiple sclerosis is an exciting area of research that may provide hope for those struggling with this debilitating disease. Although still in the early stages, studies have shown promising results in using bee venom components to reduce inflammation and promote myelin repair. As we continue to explore the art of nature, there's hope that one day bee venom could provide a viable treatment option for MS patients.

The Art of Nature: Exploring the Potential of Bee Venom in Multiple Sclerosis Clinical Trials

https://sanatio.s3.eu-west-1.amazonaws.com/6e5a0c94-f185-4b47-8c1c-737b8763f3fe_middle.jpg

The Art of Nature: Exploring the Potential of Bee Venom in Multiple Sc

Екипът на Санацио

What-are-Lion's-Mane-mushrooms-(Hericium-erinaceus)?

What are Lion's Mane mushrooms (Hericium erinaceus)?

What-are-Lion's-Mane-mushrooms-(Hericium-erinaceus)?_0_0

The lion's mane mushroom is first of all an edible mushroom, otherwise we would not write about it in such a context. And despite its fearsome name in our native language, Hericium erinaceus has irrefutable nicknames in other countries around the world. In Japan, it is known as Yamabushitake or "mushroom mountain monk". This is because the Buddhist monks of Yamabushi wear "suzukake" or a garment with long strands of hair or fur, Which resembles the mushroom. In China, it's Ho Tou Gu, the "monkey-headed mushroom." 1

What-are-Lion's-Mane-mushrooms-(Hericium-erinaceus)?_0_1

What-are-Lion's-Mane-mushrooms-(Hericium-erinaceus)?_0_2

The shaggy appearance of the lion's mane also won him titles such as:

What-are-Lion's-Mane-mushrooms-(Hericium-erinaceus)?_0_3

<ul><li style="font-weight: 400;" aria-level="1">Mushroom bearded tooth</li><li style="font-weight: 400;" aria-level="1">Mushroom bearded hedgehog</li><li style="font-weight: 400;" aria-level="1">Satir's beard</li><li style="font-weight: 400;" aria-level="1">Mushroom pompom and other even more attractive.</li></ul>All of these names point to the unique orb shape characteristic of lion's mane mushrooms, making them easy to recognize in the wild, at farmers' markets, or on the rare occasions when found elsewhere.

What-are-Lion's-Mane-mushrooms-(Hericium-erinaceus)?_0_4

Like the reishi mushroom, lion's mane has been used for medicinal purposes for thousands of years (2000 BC, to be exact). In both Chinese and Japanese medicine, lion's mane "has traditionally been used to strengthen the spleen, nourish the intestines, and also as an anticancer drug."

What-are-Lion's-Mane-mushrooms-(Hericium-erinaceus)?_0_5

But what really makes lion's mane stand out from other mushrooms (aside from the fact that it looks like a lion's lush mane and tastes like crab or lobster), it's a natural nootropic. This means that it can naturally improve cognitive function. 2

How-the-Lion's-Mane-mushroom-works---active-ingredients

How the Lion's Mane mushroom works - active ingredients 

How-the-Lion's-Mane-mushroom-works---active-ingredients_1_0

How-the-Lion's-Mane-mushroom-works---active-ingredients_1_1

Lion's mane contains various functional compounds, but two are the main substances that stand out:

How-the-Lion's-Mane-mushroom-works---active-ingredients_1_2

<ul><li style="font-weight: 400;" aria-level="1">Aromatic Hericenones</li><li style="font-weight: 400;" aria-level="1">Dieterpenoid erinacins</li></ul>No other food contains this powerful combination, which makes lion's mane exceptional.

How-the-Lion's-Mane-mushroom-works---active-ingredients_1_3

The chemical structures of these compounds are somewhat complex. Aromatics consist of loops bonded by covalent bonds (shared electrons). This adds a measure of stability known as aromaticity, hence the name.

How-the-Lion's-Mane-mushroom-works---active-ingredients_1_4

Diterpenes - naturally produced from plants, animals and fungi - have four isoprene units. Isoprene consists of two or more hydrocarbon units with a specific arrangement of carbon atoms.

How-the-Lion's-Mane-mushroom-works---active-ingredients_1_5

Neerinacin diterpenoids are found in other medicinal mushrooms and exhibit both antimicrobial and anti-inflammatory activity. But erinacins can do something unusual that non-erinacins cannot: cross the blood-brain barrier.&nbsp; (Hericenons may share this ability; but further study is needed for confirmation.) This hidden superpower is what gives the lion's mane mushroom its beneficial effect on the brain.

How-the-Lion's-Mane-mushroom-works---active-ingredients_1_6

The fruiting bodies of lion's mane contain two compounds that are called erinacin A and B. Both erinacins have been shown to promote nerve growth factor (NGF) synthesis, which has potential applications in dealing with multiple neurological conditions and disabilities. 3

How-the-Lion's-Mane-mushroom-works---active-ingredients_1_7

To date, more than 70 compounds have been identified in Hericium erinaceus. It's possible that this new data could help unravel some of the mysteries behind the lion's mane's incredible potential. 4

General-benefits-of-using-lion's-mane

General benefits of using lion's mane 

General-benefits-of-using-lion's-mane_2_0

Traditionally used to combat digestive disorders and stomach problems, the lion's mane mushroom has also been recognized as a restorative for overall health to support immunity and cognitive function.

General-benefits-of-using-lion's-mane_2_1

It is believed that the healing, regenerative nature of lion's mane helps to maintain the optimal condition of:&nbsp;

General-benefits-of-using-lion's-mane_2_2

<ul><li style="font-weight: 400;" aria-level="1">Liver</li><li style="font-weight: 400;" aria-level="1">Spleen</li><li style="font-weight: 400;" aria-level="1">Heart</li><li style="font-weight: 400;" aria-level="1">Lungs</li><li style="font-weight: 400;" aria-level="1">Kidneys</li></ul>Any "deficiency" in the body — thought to manifest externally with symptoms such as insomnia, weakness, and loss of strength — can be addressed with the help of Hericium erinaceus.

General-benefits-of-using-lion's-mane_2_3

Of course, lion's mane also has a long tradition of use for brain health. Some cultures recognize the fungus as an aid to memory, concentration, and overall mental function; Others point to the lion's mane mushroom to support nerve growth and repair, as well as for more clarity and focus.

General-benefits-of-using-lion's-mane_2_4

Seven-scientifically-based-benefits-of-lion's-mane-mushrooms

Seven scientifically based benefits of lion's mane mushrooms 

Protection-against-dementia-and-Alzheimer's-disease

Protection against dementia and Alzheimer's disease 

Protection-against-dementia-and-Alzheimer's-disease_3_0

Protection-against-dementia-and-Alzheimer's-disease_3_1

One of the most impressive benefits of lion's mane mushrooms is that they can protect against dementia and Alzheimer's disease. Studies have shown that lion's mane can improve cognitive function and memory in people with mild to moderate forms of these diseases. Alzheimer's disease is the most common form of dementia, affecting at least 50 million people.&nbsp; Dementia is a general term used to describe the deterioration of mental functions that occurs with age. Symptoms may include memory loss, difficulty reasoning and problem solving, confusion, and changes in mood or behavior.

Protection-against-dementia-and-Alzheimer's-disease_3_2

Lion's mane contains compounds known as hericistins and erinacins, which have been shown to promote nerve growth and protect neurons from damage.

Protection-against-dementia-and-Alzheimer's-disease_3_3

The unique ability of erinacins to cross the blood-brain barrier and promote regenerative activity in the brain is the most important advantage of the lion's mane mushroom. Here it is important to explain more about the so-called. nerve growth factor (NGF).

Protection-against-dementia-and-Alzheimer's-disease_3_4

Nerve growth factor functions exactly as the name suggests: it regulates the growth and reproduction of nerve cells, supports cellular health, and prevents cell death. NGF is part of a family of molecules known as neurotrophic factors that support both mature and developing neurons.

Protection-against-dementia-and-Alzheimer's-disease_3_5

Neurotrophic factors allow the brain to heal and repair itself after an injury and maintain what's known as "brain neuroplasticity" throughout life. In other words, your brain never stops responding to information, thought patterns, and external stimuli, and NGF helps strengthen or even create important neural pathways in the brain.

Studies-in-people-with-dementia-for-the-use-of-lion's-mane

Studies in people with dementia for the use of lion's mane  

Studies-in-people-with-dementia-for-the-use-of-lion's-mane_3_0

Problems with cognition can arise when the brain fails to cope with the growth and formation of new connections as we age. The resulting cognitive decline can manifest as varying degrees of memory loss or dementia. Several studies have shown the potential of lion's mane for dementia prevention and cognitive support.

Studies-in-people-with-dementia-for-the-use-of-lion's-mane_3_1

In one of them, a group of 30 adults with "mild cognitive impairment" were divided into two groups and given either lion's mane or placebo. Those who took lion's mane supplements performed better on cognitive tests at weeks 8, 12 and 16 of the study. 5

Studies-in-people-with-dementia-for-the-use-of-lion's-mane_3_2

In studies on PC12 cells — used to study brain health and function — lion's mane appeared to prevent damage and reduce the occurrence of cell death.

Studies-in-people-with-dementia-for-the-use-of-lion's-mane_3_3

Even in healthy subjects, mushroom supplementation can improve the ability to recognize and recall previously learned information ("recognition memory") by exercising activity similar to brain-derived neurotrophic factor (BDNF). BDNF supports the plasticity of neurons, making learning, memorization and cognitive processes easier to run. 6

Studies-in-people-with-Alzheimer's-for-the-use-of-lion's-mane

Studies in people with Alzheimer's for the use of lion's mane 

Studies-in-people-with-Alzheimer's-for-the-use-of-lion's-mane_3_0

Currently, no human studies have been conducted to investigate the effects of Hericium erinaceus on Alzheimer's patients. In studies on mice, however, mushroom extracts were able to reduce symptoms of memory loss and prevent the accumulation of beta-amyloid (β-amyloid) plaques. Since the accumulation of β-amyloid plaques is a key factor in the development of Alzheimer's disease, this activity can have significant implications for the prevention or even treatment of the disease.&nbsp;

Relieving-symptoms-of-anxiety-and-depression

Relieving symptoms of anxiety and depression 

Relieving-symptoms-of-anxiety-and-depression_3_0

Lion's mane isn't just a strength for memory — it can also help your mood. Hericium erinaceus extracts appear to regenerate cells in the hippocampus, the area of the brain responsible for emotional response and memories. In a mouse model, the fungus shows the potential to support neurogenesis, the process of growing new nerve cells.

Relieving-symptoms-of-anxiety-and-depression_3_1

The practical daily benefit of all this can be seen in studies related to anxiety and depression. A four-week study involving a group of 30 postmenopausal women found that cookies made with lion's mane were better than placebo cookies at reducing anxiety and irritability. 7

Relieving-symptoms-of-anxiety-and-depression_3_2

Lion's mane extracts have been shown to block the signaling power of nuclear factor-kappa beta (NF-kB), a protein complex responsible for promoting inflammation by inducing synthesis of pro-inflammatory compounds. The fungus may also reduce elevated levels of two pro-inflammatory cytokines, known as IL-6 and TNF-alpha.

Recovery-Benefits-from-Nervous-System-Injuries

Recovery Benefits from Nervous System Injuries 

Recovery-Benefits-from-Nervous-System-Injuries_3_0

The brain, spinal cord and other nerves that travel around the body are part of the nervous system. These elements collaborate to transmit and exchange messages that control almost all bodily functions. Injuries to the brain or spinal cord can be fatal. They often lead to paralysis or loss of mental abilities, and the recovery time is long.

Recovery-Benefits-from-Nervous-System-Injuries_3_1

However, lion's mane mushroom extract has been shown in studies to promote the growth and repair of nerve cells, which may help in recovering from this type of injury. Lion's mane extract may also help reduce the severity of brain damage after a stroke.

Recovery-Benefits-from-Nervous-System-Injuries_3_2

In one study, high doses of lion's mane mushroom extract given to rats immediately after a stroke helped reduce inflammation and reduce the size of stroke-related brain damage by 44%.

Improved-protection-against-ulcers-in-the-digestive-tract

Improved protection against ulcers in the digestive tract 

Improved-protection-against-ulcers-in-the-digestive-tract_3_0

Improved-protection-against-ulcers-in-the-digestive-tract_3_1

Stomach ulcers are usually a consequence of two main factors: overgrowth of H. pylori and damage to the gastric mucosa caused by long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs).

Improved-protection-against-ulcers-in-the-digestive-tract_3_2

Lion mane extract, when taken correctly, has been found to protect against the development of stomach ulcers by inhibiting the growth of H. pylori and protecting the gastric mucosa from damage. This was attributed to a polysaccharide fraction isolated from a mycelial culture of the medical fungus.&nbsp;

Improved-protection-against-ulcers-in-the-digestive-tract_3_3

Anti-inflammatory-action-and-reduction-of-oxidative-stress

Anti-inflammatory action and reduction of oxidative stress 

Anti-inflammatory-action-and-reduction-of-oxidative-stress_3_0

The lion's mane mushroom contains powerful anti-inflammatory and antioxidant chemicals that can help manage inflammatory conditions. In fact, one study comparing the antioxidant abilities of 14 different species of mushrooms found that lion's mane had the fourth highest antioxidant activity.&nbsp;

Anti-inflammatory-action-and-reduction-of-oxidative-stress_3_1

In rats, lion's mane extract reduces inflammation and indicators of oxidative stress, suggesting it may be particularly useful in the treatment of inflammatory bowel disease, liver damage and stroke. It is necessary to investigate whether it has the same effect in humans in larger studies.&nbsp;

Anti-cancer-action-of-the-mushroom-Lion's-mane

Anti-cancer action of the mushroom Lion's mane 

Anti-cancer-action-of-the-mushroom-Lion's-mane_3_0

When lion's mane extract combines with human cancer cells in a test tube, it causes cancer cells to die at a faster rate. This is seen in many types of cancer cells, including tumors of the liver, colon, stomach and blood. 8

Anti-cancer-action-of-the-mushroom-Lion's-mane_3_1

In another study, we find that diterpene shows good cytotoxic activity against two human cancer cell lines - K562, LANCAP and HEP2. 9

Antioxidant-power-and-skin-protection-with-Lion's-Mane-mushrooms

Antioxidant power and skin protection with Lion's Mane mushrooms 

Antioxidant-power-and-skin-protection-with-Lion's-Mane-mushrooms_3_0

When the body is stressed or exposed to chemicals — whether in the environment or food — compounds known as free radicals are formed. Antioxidants like those found in lion's mane have the ability to "donate" electrons to free radicals, which neutralizes compounds while protecting healthy cells. The result is less inflammation and a lower risk of cell damage.

Antioxidant-power-and-skin-protection-with-Lion's-Mane-mushrooms_3_1

According to research, lion's mane may have specific benefits associated with this anti-inflammatory activity, including:

Antioxidant-power-and-skin-protection-with-Lion's-Mane-mushrooms_3_2

<ul><li style="font-weight: 400;" aria-level="1">Reduce skin aging by increasing levels of skin antioxidants and collagen proteins</li><li style="font-weight: 400;" aria-level="1">Reduce prooxidant reactive oxygen species and increase antioxidant levels in the brain</li><li style="font-weight: 400;" aria-level="1">An increase in antioxidants and a decrease in lipid peroxidation in diabetic rat models, suggesting potential applications for the management of diabetic neuropathy.</li></ul>

If you are looking for a way to improve your brain function, memory and immunity, you can do so with the help of the lion's mane mushroom. This small mushroom is rich in nutrients that can help improve nerve function, antioxidant protection, and relieve symptoms of anxiety and depression. Their potency has also been shown in conditions such as Alzheimer's, as well as in several types of cancer.&nbsp; Lion's Mane mushrooms have powerful anti-inflammatory, antioxidant and immunostimulating properties, as well as the ability to reduce the incidence of heart disease, ulcers and diabetes in animals, and in some areas in humans. More testing is needed on the applications of this fungus in humans to reveal its potential mechanisms.

The mysterious properties of Lion's Mane mushroom (Hericium erinaceus)

https://sanatio.s3.eu-west-1.amazonaws.com/5730c625-fc05-4a3c-89c4-2f35926e4021_middle.png

The mysterious properties of Lion's Mane mushroom (Hericium erinac)

Бетина Цветкова

Medicinal-products-from-very-toxic-animals

Medicinal products from very toxic animals

Medicinal-products-from-very-toxic-animals_0_0

You would never voluntarily ingest snake venom or smear your skin with insect venom, would you? Well, before you disavow anything like this, you should know that there is actually a long history of transforming some of the most toxic substances on Earth into useful and even sometimes life-saving drugs.

Medicinal-products-from-very-toxic-animals_0_1

Scientists are increasingly looking at the deadliest corners of the animal world for drugs, as the poisons of some animals are full of molecules that evolved to perform very specific activities in small quantities. In other words, they are ideal pharmaceuticals.

Botulinum-toxin

Botulinum toxin 

Botulinum-toxin_0_0

Botulinum toxin is a neurotoxic protein that is produced by the bacterium Clostridium botulinum and other similar species, causing mild injection site paralysis. Also known as Botox, it won't bring you back from the brink of death. In fact, one gram would be enough to kill a million people, but by paralyzing the muscles of the face in very small doses, you can deprive yourself of several wrinkles. However, with this result comes some serious risks for cosmetic use, including dysphagia, muscle weakness and allergic reactions. 1

Botulinum-toxin_0_1

Botox was originally used as a treatment for ophthalmic conditions such as strabismus (crossed eyes) and twitching eyelids. Today, it is also used to prevent migraines and is just one of many terrible substances that are successfully used.

Captopril

Captopril_0_0

Captopril_0_1

The oldest toxic-inspired pharmaceutical product, and indeed the one that started looking for others, is captopril. It appeared in pharmacies in 1981 and almost instantly became popular because it treated hypertension or high blood pressure, which is a prerequisite to develop heart or kidney disease and get a heart attack, stroke or aneurysm, and all thanks to the poison of a South American viper.

Captopril_0_2

One of the great effects of this snake venom is the alarmingly rapid drop in blood pressure. This drop is useful for snakes, because the brain and muscles from which their food (other animals) have to escape do not work so well without blood. Because snakes hunt mammals, scientists believe that if they could understand how the poison works, they could better understand how our bodies regulate blood pressure.&nbsp;

Captopril_0_3

It turns out that the blood pressure regulation system is quite complex, but one major way our bodies raise blood pressure is by activating a protein called angiotensin. One of the important things angiotensin does in its active form is to make the muscle cells lining the blood vessels constrict. This means higher pressure.&nbsp;

Captopril_0_4

Scientists discovered that snake venom contains a molecule that blocks the enzyme that makes angiotensin active angiotensin the converting enzyme, or ACE. With few chemical changes, they create captopril, the first ACE inhibitor, and although captopril itself is no longer widely prescribed, ACE inhibitors are still administered every day.

Ziconotide

Ziconotide_0_0

Here in focus is the amazing and deadly marble cone snail. These slow-moving snails can eat fast-moving fish because their venom quickly paralyzes prey and is very strong. However, the advantage is that their sting does not hurt, and this is because some of the hundreds of conotoxins, the small protein toxins that cone snails produce, target the nerves that signal pain.

People are facing a huge range of diseases of different origins and innovative approaches to develop applicable therapies and new methods of treatment are constantly being sought. In this regard, one of the most suitable places to look for remedies is nature in the face of herbs, plants and some poisonous animal species.
One of the best ways to make sure we have the next generation of drugs is to protect all animal species, even those that can kill you, because they may also hold the key to curing diseases, such as autoimmune diseases or cancer.